Clinical Epidemiology Research Center (CERC)

Selected CERC Publications

The following is a list of selected recent publications by CSP Investigators at the Clinical Epidemiology Research Center. The overall portfolio of projects and articles reflects the Center's broad diversity of investigators, as well as active collaborations with other researchers both within and beyond the Center

Publications (2013 onward)

CSP#566

• Aslan M, Concato J, Peduzzi PN, Proctor SP, Schnurr PP, Marx BP, McFall M, Gleason T, Huang GD, Vasterling JJ. Design of "neuropsychological and mental health outcomes of operation Iraqi freedom: a longitudinal cohort study". Journal of Investigative Medicine: The Official Publication of The American Federation for Clinical Research 2013, 61:569-77.
• Vasterling JJ, Proctor SP, Aslan M, Ko J, Jakupcak M, Harte CB, Marx BP, Concato J. Military, demographic, and psychosocial predictors of military retention in enlisted army soldiers 12 months after deployment to Iraq. Military Medicine 2015, 180:524-32.
• Alosco ML, Aslan M, Du M, Ko J, Grande L, Proctor SP, Concato J, Vasterling JJ. Consistency of Recall for Deployment-Related Traumatic Brain Injury. The Journal of Head Trauma Rehabilitation 2016, 31:360-8.
• Vasterling JJ, Aslan M, Proctor SP, Ko J, Marx BP, Jakupcak M, Schnurr PP, Gleason T, Huang GD, Concato J. Longitudinal Examination of Posttraumatic Stress Disorder as a Long-Term Outcome of Iraq War Deployment. American Journal of Epidemiology 2016, 184:796-805.
• Vasterling JJ, Aslan M, Lee LO, Proctor SP, Ko J, Jacob S, Concato J. Longitudinal Associations among Posttraumatic Stress Disorder Symptoms, Traumatic Brain Injury, and Neurocognitive Functioning in Army Soldiers Deployed to the Iraq War. Journal of The International Neuropsychological Society: JINS 2018, 24:311-323. Epub 2017 Dec 4.
• Ciarleglio MM, Aslan M, Proctor SP, Concato J, Ko J, Kaiser AP, Vasterling JJ. Associations of Stress Exposures and Social Support with Long-Term Mental Health Outcomes Among U.S. Iraq War Veterans. Behavior Therapy 2018, 49:653-667.
• Vasterling J, Aslan M, Proctor S, Ko J, Leviyah X, Concato J. Long-term negative emotional outcomes of warzone deployment TBI. The Clinical Neuropsychologist 2020;34(6):1088-1104; doi.org/10.1080/13854046.2020.1749935.
• Jackson CE, Ciarleglio MM, Aslan M, Marx BP, Ko J, Concato J, Proctor SP, Vasterling JJ. Associations Among Increases in Posttraumatic Stress Symptoms, Neurocognitive Performance, and Long-Term Functional Outcomes in S. Iraq War Veterans. J Trauma Stress 2021 Mar 2.doi: 10.1002/jts.22663.
• Vasterling, JJ, Franz, MR, Lee, LO, Kaiser, AP, Proctor, SP, Marx, BP, Schnurr, PP, Ko, J, Concato, J, & Aslan, M.(2023). Early predictors of chronic posttraumatic stress disorder symptom trajectories in U.S. Army soldiers deployed to the Iraq war zone. Journal of Traumatic Stress, 00, 1–13. https://doi.org/10.1002/jts.22964.

CSP#572:

• Harvey PD, Siever LJ, Huang GD, Muralidhar S, Zhao H, Miller P, Aslan M, Mane S, McNamara M, Gleason T, Brophy M, Przygodszki R, O'Leary TJ, Gaziano M, Concato J. The genetics of functional disability in schizophrenia and bipolar illness: Methods and initial results for VA cooperative study #572. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of The International Society of Psychiatric Genetics 2014, 165B:381-9.
• Harvey PD, Aslan M, Du M, Zhao H, Siever LJ, Pulver A, Gaziano JM, Concato J. Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder: Implications for genomic studies. Neuropsychology 2016, 30:28-39.
• Hou L, Sun N, Mane S, Sayward F, Rajeevan N, Cheung KH, Cho K, Pyarajan S, Aslan M, Miller P, Harvey PD, Gaziano JM, Concato J, Zhao H. Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study. Genetic Epidemiology 2017, 41:152-162.
• Harvey PD, Posner K, Rajeevan N, Yershova KV, Aslan M, Concato J. Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder. Journal of Psychiatric Research 2018, 102:216-222.
• Harvey PD, Aslan, M, Sun N, Zhao, H, Concato, J. Genomics of suicidal ideation and behavior in veterans with schizophrenia and bipolar illness. Schizophr Bull.2019 Apr; 45(Suppl 2): S342. doi: 1093/schbul/sbz020.638.
• Harvey PD, Sun N, Bigdeli TB, Fanous AH, Aslan M, Malhotra AK, Lu Q, Hu Y, Li B, Chen Q, Mane S, Miller P, Rajeevan N, Sayward F, Cheung KH, Li Y, Greenwood TA, Gur RE, Braff DL; Consortium on the Genetics of Schizophrenia (COGS), Brophy M, Pyarajan S, O'Leary TJ, Gleason T, Przygodszki R, Muralidhar S, Gaziano JM, Concato J, Zhao H, Siever LJ. Genome‐wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2020 Apr;183(3):181-194. doi: 10.1002/ajmg.b.32775. Epub 2019 Dec 24.
• Aslan M, Radhakrishnan K, Rajeevan N, Sueiro M, Goulet JL, Li Y, Depp C, Concato J, Harvey PD. Suicidal ideation, behavior, and mortality in male and female US veterans with severe mental illness. Journal of Affective Disorders 2020;267:144-152; org/10.1016/j.jad.2020.02.022.
• Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Genovese G, Gupta R, Radhakrishnan K, Malhotra AK, Sun N, Lu Q, Hu Y, Li B, Chen Q, Mane S, Miller M, Cheung KH, Gur RE, Greenwood TA, Braff DL, Consortium on the Genetics of Schizophrenia (COGS), Achtyes ED, Buckley PF, Escamilla MA, Lehrer D, Malaspina DP, McCarroll SA, Rapaport MH, Vawter MP, Pato MT, Pato CN, Genomic Psychiatry Cohort (GPC) Investigators, Zhao H, Kosten TR, Brophy M, Pyarajan S, Shi Y, O’Leary TJ, Gleason T, Przygodzki R, Muralidhar S, Gaziano JM, Million Veteran Program (MVP), Huang GD, Concato J, Siever LJ, Aslan M, and Harvey PD. Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans. Schizophrenia Bulletin 2021 Mar 16;47(2):517-529; doi.org/10.1093/schbul/sbaa133.
• Harvey PD, Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Radhakrishnan K, Huang GD, Aslan Cooperative Studies Program (CSP) #572: A Study of Serious Mental Illness in Veterans as a Pathway to personalized medicine in Schizophrenia and Bipolar Illness. Pers. Med. Psychiatry. 2021 Jul;27-28:10.1016/j.pmip.2021.100078. doi: 10.1016/j.pmip.2021.100078.
• Bigdeli TB, Voloudakis G, Barr PB, Gorman B, Genovese G, Peterson RE, Burstein DE, Velicu VI, Li Y, Gupta R, Mattheisen M, Tomasi S, Rajeevan N, Sayward F, Natarajan S, Malhotra AK, Shi Y, Zhao H, Kosten TR, Concato J, O’Leary T, Przygodzki R, Gleason T, Pyarajan S, Brophy M, Cooperative Studies Program (CSP) #572, Million Veteran Program (MVP), Siever LJ, Huang GD, Muralidhar S, Gaziano JM, Aslan M, Fanous AH, Harvey PD, Roussos P. Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System. JAMA Psychiatry.2022;79(11):1092–1101. doi:10.1001/jamapsychiatry.2022.2742.
• Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann AC, Lipsky RK, Kosten TR, Aslan M, Harvey PD, Kimbrel NA, Beckham JC; Million Veteran Program (MVP); Cooperative Studies Program (CSP) #572. Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. JAMA Psychiatry. 2024 Feb 1;81(2):188-197. doi: 10.1001/jamapsychiatry.2023.4141. PMID: 37938835; PMCID: PMC10633411.
• Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, Brophy M, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, DeLisi LE, Kimbrel NA, Beckham JC, Swann AC, Kosten TR, Fanous AH; Cooperative Studies Program (CSP) #572; Aslan M, Harvey PD. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Mol Psychiatry. 2024 Mar 15. doi: 10.1038/s41380-024-02472-1. Epub ahead of print. PMID: 38491344.

CSP#575B

• Radhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B. International Journal Of Methods In Psychiatric Research 2019, 28:e1767.
• Harrington KM, Quaden R, Stein MB, Honerlaw JP, Cissell S, Pietrzak RH, Zhao H, Radhakrishnan K, Aslan M, Gaziano JM, Concato J, Gagnon DR, Gelernter J, Cho K. Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans. Journal of Traumatic Stress 2019, 32:226-237.
• Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86:365-376.
• Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22:1394-1401.
• Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Yuk-Lam AH, Posner D, PTSD Working Group of the Psychiatric Genomics Consortium (PGC), Traumatic Stress Brain Research Study Group, VA Million Veteran Program, VA Cooperative Studies Program, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample. bioRxiv, Sep 2019.
• Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF; Million Veteran Program; Stein MB. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. Am J Psychiatry. 2020 Mar 1;177(3):223-232.
• Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H; Department of Veterans Affairs Cooperative Studies Program (no. 575B); VA Million Veteran Program; Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nat Genet. 2021 Feb;53(2):174-184.
• Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS; 23andMe Research Team; Million Veteran Program; Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nat Neurosci. 2021 Jul;24(7):954-963.
• Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X; 23andMe Research Team; Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D. Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nat Genet. 2022 Aug;54(8):1125-1132.
• Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. Mol Psychiatry. 2022 Oct;27(10):3970-3979.
• Overstreet C, Levey DF, Zhou H, Harrington KM, Quaden R, Stein MB, Gelernter J, Pietrzak RH; Million Veteran Program. Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants. Psychiatry Res. 2023 Jan, 319:114994.
• Gelernter J, Levey D, Galimberti M, Harrington K, Zhou H, Adhikari K, Gaziano MJ, Eliott D, Stein MB. Genomewide association study of epiretinal membrane: discovery of significant risk loci in each of three American populations. medRxiv. 2023 Apr.
• Austin-Zimmerman I, Levey DF, Giannakopoulou O, Deak JD, Galimberti M, Adhikari K, Zhou H, Denaxas S, Irizar H, Kuchenbaecker K, McQuillin A; Million Veteran Program; Concato J, Buysse DJ, Gaziano JM, Gottlieb DJ, Polimanti R, Stein MB, Bramon E, Gelernter J. Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. Nat Commun. 2023 Sep 28;14(1):6059.

CSP#2006:

• Krishnan Radhakrishnan, Elizabeth R. Hauser, Renato Polimanti, Drew A. Helmer, Dawn Provenzale, Rebecca B. McNeil, Alysia Maffucci, Rachel Quaden, Hongyu Zhao, Stacey B. Whitbourne, Kelly M. Harrington, Jacqueline Vahey, Joel Gelernter, Daniel F. Levey, Grant D. Huang, John Michael Gaziano, John Concato, and Mihaela Aslan. Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006. Brain Sci. 2021, 11, 845; doi: 10.3390/brainsci11070845
• Linh M. Duong, Alice B. S. Nono Djotsa, Jacqueline Vahey, Lea Steele, Rachel Quaden, Kelly M. Harrington, Sarah T. Ahmed, Renato Polimanti, Elani Streja, John Michael Gaziano, John Concato, Hongyu Zhao, Krishnan Radhakrishnan, Elizabeth R. Hauser, Drew A. Helmer, Mihaela Aslan, and Elizabeth J. Gifford. Association of Gulf War Illness with Characteristics in Deployed vs. Non-Deployed Gulf War Era Veterans in the Cooperative Studies Program 2006/Million Veteran Program 029 Cohort: A Cross-Sectional Analysis. Int. J. Environ. Res. Public Health 2023, 20, 258; doi: 10.3390/ ijerph20010258
• Sarah M.C. Colbert, Frank R. Wendt, Gita A. Pathak, Matthew C. Keller, Renato Polimanti, and Emma C. Johnson. Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts. AJHG 2023, 110, 6; doi: 10.1016/j.ajhg.2023.04.007
• Frank R. Wendt, Gita A. Pathak, Jacqueline Vahey, Xuejun Qin, Dora Koller, Brenda Cabrera‑Mendoza, Angela Haeny, Kelly M. Harrington, Nallakkandi Rajeevan, Linh M. Duong, Daniel F. Levey, Flavio De Angelis, Antonella De Lillo, Tim B. Bigdeli, Saiju Pyarajan, VA Million Veteran Program, John Michael Gaziano, Joel Gelernter, Mihaela Aslan, Dawn Provenzale, Drew A. Helmer, Elizabeth R. Hauser, and Renato Polimanti, on behalf of Department of Veteran Affairs Cooperative Study Program (#2006). Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program. Hum Genomics 17, 46 (2023); doi:10.1186/s40246-023-00487-3
• Kelly M. Harrington, Rachel Quaden, Lea Steele, Drew A. Helmer, Elizabeth R. Hauser, Sarah T. Ahmed, Mihaela Aslan, Krishnan Radhakrishnan, Jacqueline Honerlaw, Xuan-Mai T. Nguyen, Sumitra Muralidhar, John Concato, Kelly Cho, J. Michael Gaziano, Stacey B. Whitbourne, and on behalf of the VA Million Veteran Program. The Million Veteran Program 1990–1991 Gulf War Era Survey: An Evaluation of Veteran Response, Characteristics, and Representativeness of the Gulf War Era Veteran Population. J. Environ. Res. Public Health 2024, 21, 72; doi.org/10.3390/ijerph21010072
• Lea Steele1, Rachel Quaden, Sarah T. Ahmed, Kelly M. Harrington, Linh M. Duong, John Ko, Elizabeth J. Gifford, Renato Polimanti, J. Michael Gaziano, Mihaela Aslan, Drew A. Helmer, Elizabeth R. Hauser, and on behalf of the Department of Veterans Affairs Cooperative Studies Program #2006 and the VA Million Veteran Program. Association of deployment characteristics and exposures with persistent ill health among 1990-1991 Gulf War veterans in the VA Million Veteran Program. Environ Health 23, 92 (2024). https://doi.org/10.1186/s12940-024-01118-7
• Gita A Pathak, Dora Koller, Brenda Cabrera-Mendoza, Alice B S Nono Djotsa, Frank R Wendt, Antonella De Lillo, Eleni Friligkou, Jun He, Manuela R Kouakou, Linh M Duong, Jacqueline Vahey, Lea Steele, Rachel Quaden, Kelly M Harrington, Sarah T Ahmed, J Michael Gaziano, John Concato, Hongyu Zhao, Krishnan Radhakrishnan, Joel Gelernter, Elizabeth Gifford, Mihaela Aslan, Drew A Helmer, Elizabeth R Hauser, Renato Polimanti, On behalf of Department of Veteran Affairs Cooperative Study Program (#2006), Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program, Human Molecular Genetics, 2025;, ddaf075, https://doi.org/10.1093/hmg/ddaf075

CSP#2038:

• Kristina L. Bajema, MD, MSc; Xiao Qing Wang, MPH; Denise M. Hynes, MPH, PhD, RN; Mazhgan Rowneki, MPH; Alex Hickok, MS; Francesca Cunningham, PharmD; Amy Bohnert, PhD, MHS; Edward J. Boyko, MD, MPH; Theodore J. Iwashyna, MD, PhD; Matthew L. Maciejewski, PhD; Elizabeth M. Viglianti, MD, MPH, MSc; Elani Streja, PhD; Lei Yan, PhD; Mihaela Aslan, PhD; Grant D. Huang, MPH, PhD; AND George N. Ioannou, BMBCh, MS. Early Adoption of Anti–SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022. JAMA Netw Open. 2022;5(11); doi:10.1001/2022.41434
• Kristina L. Bajema, MD, MSc; Kristin Berry, PhD; Elani Streja, PhD; Nallakkandi Rajeevan, PhD; Yuli Li, MS; Pradeep Mutalik, MD; Lei Yan, PhD; Francesca Cunningham, PharmD; Denise M. Hynes, MPH, PhD, RN; Mazhgan Rowneki, MPH; Amy Bohnert, PhD, MHS; Edward J. Boyko, MD, MPH; Theodore J. Iwashyna, MD, PhD; Matthew L. Maciejewski, PhD; Thomas F. Osborne, MD; Elizabeth M. Viglianti, MD, MPH, MSc; Mihaela Aslan, PhD; Grant D. Huang, MPH, PhD; and George N. Ioannou, BMBCh, MS. Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes. Ann Intern Med. Jun 6 2023; doi:10.7326/m22-3565
• Lei Yan, PhD; Elani Streja, PhD; Yuli Li, MS; Nallakkandi Rajeevan, PhD; Mazhgan Rowneki, MPH; Kristin Berry, PhD; Denise M. Hynes, MPH, PhD, RN; Francesca Cunningham, PharmD; Grant D. Huang, MPH, PhD; Mihaela Aslan, PhD; George N. Ioannou, BMBCh, MS; AND Kristina L. Bajema, MD, MSc. Anti-SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Netw Open. 2023 Aug 1;6(8):e2331249. doi: 10.1001/jamanetworkopen.2023.31249
• George N. Ioannou, BMBCh, MS; Kristin Berry, PhD; Nallakkandi Rajeevan, PhD; Yuli Li, MS; Pradeep Mutalik, MD; Lei Yan, PhD; David Bui, PhD; Francesca Cunningham, PharmD; Denise M. Hynes, MPH, PhD, RN; Mazhgan Rowneki, MPH; Amy Bohnert, PhD, MHS; Edward J. Boyko, MD, MPH; Theodore J. Iwashyna, MD, PhD; Matthew L. Maciejewski, PhD; Thomas F. Osborne, MD; Elizabeth M. Viglianti, MD, MPH, MSc; Mihaela Aslan, PhD; Grant D. Huang, MPH, PhD; and Kristina L. Bajema, MD, MSc. Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among U.S. Veterans: A Target Trial Emulation. Ann Intern Med. Oct 31 2023; doi:10.7326/M23-1394
• Lei Yan, David Bui, Yuli Li, Nallakkandi Rajeevan, Mazhgan Rowneki, Kristin Berry, Stephanie Argraves, Yuan Huang, Denise M. Hynes, Francesca Cunningham, Grant D. Huang, Mihaela Aslan, George N. Ioannou, and Kristina L. Bajema. Identifying Veterans Who Benefit From Nirmatrelvir-Ritonavir: A Target Trial Emulation. Clinical Infectious Diseases, Jun 12 2024; doi:1093/cid/ciae202
• David P. Bui, Kristina L. Bajema, Yuan Huang, Lei Yan, Yuli Li, Nallakkandi Rajeevan, Kristin Berry, Mazhgan Rowneki, Stephanie Argraves, Denise M. Hynes, Grant Huang, Mihaela Aslan, and George N. Ioannou. Development of a prediction model for 30-day COVID-19 hospitalization and death in a national cohort of Veterans Health Administration patients-March 2022-April 2023. PLOS One. 2024 Oct 4;19(10):e0307235. doi: 10.1371/journal.pone.0307235.
• Kristina L Bajema, Lei Yan, Yuli Li, Stephanie Argraves, Nallakkandi Rajeevan, Alexandra Fox, Robert Vergun, Kristin Berry, David Bui, Yuan Huang, Hung-Mo Lin, Denise M Hynes, Cynthia Lucero-Obusan, Patricia Schirmer, Francesca Cunningham, Grant D Huang, Mihaela Aslan, and George N Ioannou. Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study. The Lancet Infectious Diseases. Elsevier. 2025/01/22; 1473-30992025/01/22; doi: 10.1016/S1473-3099(24)00796-5.
• Kristina L. Bajema, MD; David P. Bui, PhD; Lei Yan, PhD; Yuli Li, MS; Nallakkandi Rajeevan, PhD; Robert Vergun, PhD; Kristin Berry, PhD; Yuan Huang, PhD; Hung-Mo Lin, PhD; Mihaela Aslan, PhD; and George N. Ioannou, BMBCh. Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus. JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7452
• George N. Ioannou, BMBCh, MS; Kristin Berry, PhD; Nallakkandi Rajeevan, PhD; Yuli Li, MS; Lei Yan, PhD; Yuan Huang, PhD; Hung-Mo Lin, PhD; David Bui, PhD; Denise M. Hynes, MPH, PhD, RN; Mazhgan Rowneki, MPH; Amy Bohnert, PhD, MHS; Edward J. Boyko, MD, MPH; Theodore J. Iwashyna, MD, PhD; Matthew L. Maciejewski, PhD; Valerie A. Smith, DrPH; Theodore S.Z. Berkowitz, MS; Ann M. O’Hare, MD; Elizabeth M. Viglianti, MD, MPH, MSc; Mihaela Aslan, PhD; and Kristina L. Bajema, MD, MSc. Effectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up: A Target Trial Emulation. Ann Intern Med. [Epub 4 February 2025]. doi:10.7326/ANNALS-24-01015
• George N Ioannou, Kristin Berry, Nallakkandi Rajeevan, Yuli Li, Lei Yan, Yuan Huang, David Bui, Denise M Hynes, Mazhgan Rowneki, Alex Hickok, Meike Niederhausen, Troy A Shahoumian, Amy Bohnert, Edward J Boyko, Anna Korpak, Alexandra Fox, Aaron Baraff, Theodore J Iwashyna, Matthew L Maciejewski, Valerie A Smith, Theodore S Z Berkowitz, John A Pura, Paul Hebert, Edwin S Wong, Ann M O’Hare, Thomas F Osborne, Elizabeth M Viglianti, Mihaela Aslan, Kristina L Bajema, Target Trial Emulation of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Versus No Infection and Risk of Post–Coronavirus Disease 2019 Conditions in the Omicron Variant Versus Prior Eras, Clinical Infectious Diseases, 2025;, ciaf087, https://doi.org/10.1093/cid/ciaf087

• CSP#2012:

• Lee KM, Heberer K, Gao A, Becker DJ, Loeb S, Makarov DV, Gulanski B, DuVall SL, Aslan M, Lee J, Hauger R, Shih MC, Lynch J, Rettig M. A population-level analysis of the protective effects of androgen deprivation therapy against COVID-19 disease incidence and severity. Front. Med. 2022 9:774773. doi: 10.3389/fmed.2022.774773. EPub 2022 May 4
• Gulanski B, Goulet J, Radhakrishnan K, Ko J, Li Y, Rajeevan N, Lee KM, Heberer K, Lynch JA, Streja E, Mutalik P, Cheung KH, Concato J, Shih MC, Lee JS, Aslan M. Metformin Prescription for U.S. Veterans with Prediabetes, 2010-2019. Journal of Investigative Medicine. 2023;0(ja). doi:10.1177/10815589231201141
• Cogill S, Nallamshetty S, Fullenkamp N, Heberer K, Lynch J, Lee KM, Aslan M, Shih M-C, and Lee JS. (2024) Predicting clinical outcomes of SARS-CoV-2 infection during the Omicron wave using machine learning. PLOS ONE 19(4): e0290221. https://doi.org/10.1371/journal.pone.0290221
• Lipska KJ, Oladele C, Zawack K, Gulanski B, Mutalik P, Reaven P, Lynch JA, Lee KM, Shih M-C, Lee JS, Aslan M. Association of race and ethnicity with prescriptions for continuous glucose monitoring systems among a national sample of veterans with diabetes on insulin therapy. Diabetes Technology and Therapeutics (in press)

• MVP:

• Gaziano JM, Concato J, Brophy M, Fiore L, Pyarajan S, Breeling J, Whitbourne S, Deen J, Shannon C, Humphries D, Guarino P, Aslan M, Anderson D, LaFleur R, Hammond T, Schaa K, Moser J, Huang G, Muralidhar S, Przygodzki R, O'Leary TJ. Million Veteran Program: A mega-biobank to study genetic influences on health and disease. Journal of Clinical Epidemiology CSP#2032 - Implementation and Research Operations Core:
• Mutalik P, Cheung K-H, Green J, Buelt-Gebhardt M, Anderson KF, Jeanpaul V, McDonald L, Wininger M, Li Y, Rajeevan N, Jessel PM, Moore H, Adabag S, Raitt MH, Aslan M. Combining Rule-based NLP-lite with Rapid Iterative Chart Adjudication for Creation of a Large, Accurately Curated Cohort from EHR data: A Case Study in the Context of a Clinical Trial Emulation. Journal of the American Medical Informatics Association (JAMIA) (in press)

CSP#2032 - Methods Core:

• Dickerman BA, Gerlovin H, Madenci AL, Kurgansky KE, Ferolito BR, Figueroa Muñiz MJ, Gagnon DR, Gaziano JM, Cho K, Casas JP, Hernán MA. Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans. N Engl J Med. 2022 Jan 13;386(2):105-115.
• Dickerman BA, Madenci AL, Gerlovin H, Kurgansky KE, Wise JK, Figueroa Muñiz MJ, Ferolito BR, Gagnon DR, Gaziano JM, Cho K, Casas JP, Hernán MA. Comparative Safety of BNT162b2 and mRNA-1273 Vaccines in a Nationwide Cohort of US Veterans. JAMA Intern Med. 2022 Jul 1;182(7):739-746.
• Dickerman BA, Gerlovin H, Madenci AL, Figueroa Muñiz MJ, Wise JK, Adhikari N, Ferolito BR, Kurgansky KE, Gagnon DR, Cho K, Casas JP, Hernán MA. Comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans. Nat Microbiol. 2023 Jan;8(1):55-63.
• Szmulewicz A, Madenci A, Ferguson R, Liang MH, Lew R, Katz IR, Hernán MA. Estimating the per-protocol effect of lithium on suicidality in a randomized trial of individuals with depression or bipolar disorder. J Psychopharmacol. 2023 Jun;37(6):539-544.
• Li G, Gerlovin H, Figueroa Muñiz MJ, Wise JK, Madenci AL, Robins JM, Aslan M, Cho K, Gaziano JM, Lipsitch M, Casas JP, Hernán MA, Dickerman BA. Comparison of the Test-negative Design and Cohort Design with Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness. 2024 Mar;35(2):137-149.

POLYPHARM01

• Lei Yan, Cassidy E. Henegar, Vincent C. Marconi, Kirsha S. Gordon, Charles Hicks, Vani Vannappagari, Amy C. Justice, and Mihaela Aslan. Effectiveness of dolutegravir-based regimens compared to raltegravir-, elvitegravir-, bictegravir, and darunavir-based regimens among older adults with HIV in the Veterans Aging Cohort Study (VACS). AIDS Res Ther 21, 96 (2024). https://doi.org/10.1186/s12981-024-00681

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